The Fate of Sodium Benzoate in the Human Organism. by H. D. Dakin
نویسنده
چکیده
In spite of a large number of investigations, one encounters in the current literature the most diverse statements concerning the fate of salts of benzoic acid in the human organism. Only one fact is apparently accepted by all as settled beyond question, namely, that part of the benzoate is converted into a hippurate through union with glycocoll. Upon the question as to horn nearly this reaction proceeds t.on-ards comI)letion there appears to be no agreement of opinion; some authors contending that the conversion is practically quantitative while Brugsch and others state that in carnivorous animals and in man the amount of uncombined benzoate excreted exceeds the amount of benzoic acid paired with glycocoll. About a year ago a careful study appeared by Letvinski’ “ Ueber die Grenzen der Hippursaurebildung beim Menschen, ” in which he claimed to have recovered in the form of hippuric acid practically the whole of large doses of sodium benzoate (I 2 to 20 grams) given to men. When extremely large doses were given (40 grams and over) a certain proportion of the benzoate was excreted unchanged in the urine which also contained reducing substances and was dextro-rotatory. At the same time Seo shon-ed that bacterial decomposition may affect the reconversion of hippuric acid into benzoic acid and that therefore bacterial contamination of the urine was a source of error to be guarded against in investigations of the kind in question. This work of Lewinski has been subjected by Brugsch2 to an extremely hostile criticism. By methods which, to the writer
منابع مشابه
The Mode of Oxidation in the Animal Organism of Phenyl Derivatives of Fatty Acids. Part Iv. Further Studies on the Fate of Phenylpropionic Acid and Some of Its Derivatives. by H. D. Dakin
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